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Figure 3 MetM-Wntlung cells co-transplanted with young mammary fat pad (MFP) adipose tissue promote tumor growth in a metM-Wntlung cell transplant model of TNBC. (A) Young donor MFP adipose enhances tumor growth in young recipient orthotopic transplant model of TNBC. (B) In contrast, young donor metM-Wntlung cells co-transplanted with young MFP adipose do not enhance tumor growth in young recipient orthotopic transplant model of TNBC. (C) In contrast, aged donor MFP adipose enhances tumor growth in young recipient orthotopic transplant model of TNBC. (D) In contrast, aged donor metM-Wntlung cells co-transplanted with young MFP adipose do not enhance tumor growth in young recipient orthotopic transplant model of TNBC. (E) Young donor MFP adipose does not enhance tumor growth in aged recipient orthotopic transplant model of TNBC. (F) Aging host adipose does not enhance tumor growth in young recipient orthotopic transplant model of TNBC. (G) In contrast, aged donor metM-Wntlung cells co-transplanted with young MFP adipose enhance tumor growth in young recipient orthotopic transplant model of TNBC. (H) In contrast, aged donor metM-Wntlung cells co-transplanted with young MFP adipose do not enhance tumor growth in aged recipient orthotopic transplant model of TNBC. (I) Young donor adipose does not enhance tumor growth in aged recipient orthotopic transplant model of TNBC. (J) MetM-Wntlung cells do not enhance tumor growth in young recipient orthotopic transplant model of TNBC in either young or aged host adipose. (K) 827ec27edc