Sigmaplot 13 0 Crack Cocaine
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Because in the previous experiment we had found that cocaine remained a strong discriminative stimulus for heroin self-administration, we next tested whether rats would show behavioral sensitization to the drug. In the experiments shown in Figure 4, rats were trained for heroin self-administration and tested for cocaine choice. After 3-5 days of abstinence, rats received the opportunity to sample cocaine (0.25 mg, i.v.) on 2 consecutive days. As shown in Figure 4A, rats showed significant behavioral sensitization to cocaine (two-way ANOVA, interaction between testing sessions, F
0.0003). In a second experiment, we tested the behavioral effects of blocking NMDA receptors with its competitive antagonist, MK-801 (3 mg/kg, i.p.). As shown in Figure 4B, rats injected with MK-801 showed no preference for cocaine over water after cocaine self-administration (two-way ANOVA, interaction between testing sessions, F
0.0451). In addition, rats self-administered heroin for at least 5 days after 3-5 days of abstinence (Figure 4C). Note that although rats were trained in a context associated with heroin, on the test day they were presented with cocaine choice in a different context. Importantly, as shown in Figure 4C, rats showed behavioral sensitization to heroin (two-way ANOVA, interaction between testing sessions, F
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